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IAEA/MU/BBC

Advance Training Course -Cum- Master Degree Program

(MSc - Bone and Tissue Banking)

Curriculum (Under Review)

Quality Assurance In Radiation Sterilization to Tissue Bankers

 

Introduction:

The need for trained and skilled personnel in Tissue Bank s day to day operation was felt highly, immediately after the conception of many Tissue banks all over the world. The surgeon or doctor, who is the head of Tissue bank does not usually have much time from his busy schedule to take care of all the activities of the Bank, like tissue recovery, processing, storage data processing tissue donation campaigns, public and professional awareness programms. In the event, fellows are involved in the routine activities; work done is for short time as they are more interested in their certificates.

In 1992, at the IAEA arranged project formulation meeting in Manila, Philippines, the Bangkok Biomaterial Center proposed the idea to start an Advance Training Course of master degree international programme in Tissue Banking. It was also suggested to Thailand at this meeting, to start a Post-Graduate training course for neighboring RCA member countries. A request was made to IAEA to send an expert for this assignment. A feasibility study was carried out. The Dean of Faculty of Graduate School accepted the idea of Advance Training Course under a M.Sc. Programme (Tissue Banking) in Mahidol University. The first batch of this Advance Training Course was flagged off on the 31st March 1999 at the Bangkok Biomaterial Center.

The commencement of this Advance Training Course-cum-Master Degree Programme in Bone and Tissue Banking is the first course of its kind in the world. With the recognition of this Programme by IAEA, Asia-Pacific Association of Surgical Tissue Banking, Office of Atomic Energy for Peace and Regional Co-operative Agreement countries of the Asia-Pacific Region the Programme has been able to drive lot of enthusiasm and has been highly regarded by the Tissue Banking fraternity.

 

 

 

 

Prof. Glyn O. Phillips IAEA expert and advisor during a meeting with Prof. Yongyudh Vajaradul regarding the formulation of Master Degree Curriculum, Bangkok 1994

 

 

 

 

 

 

 

Senior IAEA officer Mr. Reyad Kamel visiting the BBC for a meeting with Prof. Yongyudh Vajaradul regarding finalization of the Master Degree Program 1997.

 

 

 

 

 

Mr. Hideo Tatzusaki - Head of Radiation Biology Unit, IAEA having discussion with Prof. Yongyudh Vajaradul regarding the IAEA Advance Training Course cum Master Degree Program, Bangkok

 

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Mr. Nai Cheng Xu IAEA country officer visitng the BBC for a meeting regarding the set up of keratinocyte cell culture and observation of first batch of IAEA Advance Training Course, Bangkok 1994.

 

AIMS & OBJECTIVES:

To establish training and teaching on the advance topics Tissue Banking to students of Master Degree Programme at the Bangkok Biomaterial Center and try to make the methods and techniques, useful for clinical applications.

To fulfil the need for IAEA/RCA project in the aspect of advance training programme in the Asia Pacific region for tissue bank operators.

Advance training center for BANGKOK BIOMATERIAL CENTER, Mahidol University to teach Tissue Banking as part of Curriculum in the Master Degree programme (IAEA/RAS/7/008).

Train the trainer for teaching the tissue bank staff

Research and development of Tissue Banking in the Asia - Pacific Region

Upgrade the standards of Tissue Bank staffs in the Asia-Pacific Region

Promote the use of Radiation Sterilization of Tissue grafts.

 

ASSOCIATE ORGANIZATIONS

Bangkok Biomaterial Center, Faculty of Medicine Siriraj Hospital, Mahidol University.

International Atomic Energy Agency (IAEA)

Office of Atomic Energy for Peace (OAEP)

Faculty of Graduate Studies, Mahidol University

Ministry of Science, Technology and Environment

 

STUDY CENTERS

BANGKOK BIOMATERIAL CENTER, SIRIRAJ HOSPITAL, MAHIDOL UNIVERSITY

 

PROGRAMME SCHEDULE

1st BATCH

1st Semester started on 31st March 1999

2nd Semester started on 1st October 1999

2ND BATCH

1ST Semester started on 31st March 2000

2nd Semester will started 1st October 2000

3RD BATCH

1ST Semester will start on 31st March 2002

2nd Semester will start from 1st October 2002

 

ADMISSION REQUIREMENTS

Any nationality

Possess a Bachelor degree in Science i.e. B.Sc. any discipline

G.P.A 2.5 (minimum)

One year of working experience in tissue banking

Should have good knowledge of written/spoken English

Selection criteria for students

Student selection will be done either by a written or oral examination according to the criteria set in the master degree board.

Language of Instruction

The medium of instruction is English. The thesis shall also be submitted in English.

Requirements for qualification of M.Sc. (Cell and Tissue Banking)

There are 2 semester per year and are counted by the credit units.

The credit units system is as follows

Lectures shall be one hour/week. The total number of lecture units shall not be less than 16 hours/semester and will be counted as one (1) credit unit

Practicals/laboratory unit will be 2-3 hours/week or 32-48 hours/semester and will be counted as one (1) credit unit

Thesis work shall be 4 hours/week or 64 hours/semester and is counted as one credit unit

Students must obtain B Grade in the Subject Cell & Molecular Biology in order to take-up the dissertation work.

Every student must complete 2 semesters of study on a full time basis. The other  2 semesters of study can be completed from the home country before submission of the dissertation work for the award of the degree.

Duration of the Course

Maximum 5 years

Minimum 2 years

CRITERIA FOR GRADUATION

Students are registered for full time, and the total credits is not be more than 15 per semester or follow the program director.

Evaluation and graduation

Evaluation: The evaluation is done following the covenant of Mahidol University

Graduation:

The period of study will not be less than 2 semesters

Study of various subjects according to the curriculum i.e. not less than 12 credits for the course work and 24 credits for thesis work.

Students must pass the examination of English.

The dissertation should be proposed and shall pass the oral examination finally in the first year.

Students: 5-10 students per batch

 

CENTER FACILITIES AND RESOURCES

BIBILOGRAPHY (Library)

Faculty libraries in Mahidol University has the following units of books/printed materials, available:

Center library 1,200 items

Faculty library, Siriraj Hospital 1,150 items

Faculty of Science library 800 items

Bangkok Biomaterial Center Library 350 items

 

Electronic Information System

CD-ROM Medline at the libraries of Mahidol University

24hrs Internet Service via Mahidol University Computer Network (MUCNet)

COMPONENTS OF THE CURRICULUM

The total credit unit should not be less than 36 credits.

The structure of the curriculum according to the Ministry of University Affairs i.e. the standard curriculum 1997 Master Degree project category A, form A No 2 is detailed as follows:

Special Subjects 19 units

Elective Subjects 5 units

Thesis 12 units

Curriculum Sequence

Special Subjects 19 Units

SIMI 501 Medical Microbiology 3 (2-2) credits

SIRE 502 Research Methodology 1 (1-0) credits

SIBT 614 Basic Anatomy and Histology 1 (1-0) credits

SIBT 611 Seminar 2 (1-0) credits

SIBT 612 Tissue and Biomaterial Implantation 4 (2-0) credits

SIBT 613 Advances in Tissue Banking 6 (2-0) credits

Elective Subjects 5 Units

SIIM 501 Immunology 2 (2-0) credits

GRID 612 Cell and Molecular Biology 3 (3-0) credits

TMID 513 Biostatistics 2 (2-0) credits

Thesis 12 Units

SIBT 698 Research M.Sc. Thesis 12 credits

COURSE DESCRIPTIONS

SIIM 501 Immunology 2 (2-0) credits

This course is aimed as an introductory course in immunology for graduate students who will continue their study in the field of immunology and related life sciences. The course focuses on fundamental concepts of the immune response, covering the components and the development of the immune system, the non-specific and specific immune responses the mechanisms, consequences and regulations of humoral and cell-mediated immune responses.

SIRE 502 Research Methodology 1 (1-0) credits

Study on the various aspects about methods and techniques clinical, or laboratory research on transplantation, technology of bio-tissue and biomaterial implantation or related research

GRID 612 Cell and Molecular Biology 3 (3-0) credits

The subject is supposed to acquaint students with current facts, principles and concepts concerning the structure and function of the living cell at both the morphological and molecular level. In order to achieve these goals, the course is divided into 13 units, namely, evolution of the cell; molecular organization of the cell; techniques in the study of the cell; cell plasma membrane and transport phenomena; genetic mechanisms of the cell; cell cytoplasmic organelles; cell cytoskeleton; cellular metabolism and energy conservation; cell growth, division and cycle; cellular communication; cell specialization, cellular response to injury; cell technology and experimental models of human diseases.

SIBT 611 Seminar 2 (1-0) credits

Seminar on the relevant researches in technology and Medical Biomaterial Implantation selected by the student to be the background of the thesis proposal:

Cryopreservation of tissue

Interface problems

Keratinocyte culture

Role of chondrocyte in tissue banking

Donor selection

Tissue retrieval

Tissue processing

Cornea preservation

Growth factors in tissue transplantation

Bone marrow transplantation

Heart - lung transplantation

Renal transplantation

Liver transplantation

Nerve cell transplantation

Endocrinal cell transplantation

Tissue rejection

Blood transfusion

Fibrin glue application

Clinical

Neurosurgery

Oral surgery

Orthopedics

Plastic surgery

Dentistry

Ophthalmology

ENT

General surgery

Hematology

Total quality management in tissue banking

Graft sterilization

TMID 513 Biostatistics 2 (2-0) credits

The subject consists of lectures and practical session on the use of statistical methods in biomedical research. The aim is to emphasize the basic concepts, their practical uses in data analysis and interpretation of results of biomedical and clinical research concerning. The main part of the course is devoted to the teaching of statistical methodology with practical examples drawn from the biomedical work. The topics include simple statistical methods for assessing sampling errors or the role chance ( t-test, Chi-square test etc. ), simple linear regression and correlation.

SIBT 614 Basic Anatomy and Histology 1 (1-0) credits

Anatomy and histology of the organ that are used for transplantation in order to know about external and internal morphology and function of cells, tissue and organs in the human body.

SIMI 501 Medical Microbiology 3 (2-2) credits

Study the basics about Microbiological screenings and tests procedures and processing.

SIBT 612 Tissue and Biomaterials Implantation

Types, properties and the selection of tissues and biomaterials for implantation and transplantation.The processes of implantation, technique, complications, advantage and disadvantage of each process including ethical aspects of Transplantations. Lectures on the relevant topics of Tissue Banking.

Cryopreservation of tissue

Interface problems

Keratinocyte culture

Role of chondrocyte in tissue banking

Donor selection

Tissue retrieval

Tissue processing

Cornea preservation

Growth factors in tissue transplantation

Bone marrow transplantation

Heart - lung transplantation

Renal transplantation

Liver transplantation

Nerve cell transplantation

Endocrinal cell transplantation

Tissue rejection

Blood transfusion

Fibrin glue application

Total quality management in tissue banking

Graft sterilization

Tissue harvesting

Processings > pasteurization

Sterilization - workshop

Quality control Preservation techniques

SIBT 613 Advances in Tissue Banking 6 (5-0) credits

Lectures and research in the technology and medical biomaterial implantation selected by the student to be the background of the thesis proposal. This comprises of topics as Clinical Appication of Allografts in Dentistry, ENT, General and Oral Surgery, Neurosurgery, Orthopaedic Surgery, Cardiovascular Surgery, Ophthalmology, Plastic Surgery, Hematology, Donor Selection / Tissue recovery and processing. Transplantation surgeries like Heart transplantation, Liver transplantation, Renal transplantation, Nerve cell transplantation, Endocrinal cell transplantation, Implantation of Biomaterial and Tissue reaction, Keratinocyte Culture, Role of Chondrocyte in tissue banking, Cryopreservation technology and Radiation sterilization of tissue allograft, problems relating to interface, Fibrin glue processing, total quality management in Tissue banking etc. Biomaterial preservation, cell and tissue culture eg. keratinocyte cell culture, corneal preservation, the use of ceramic in surgery, etc.

Assignments & Reports

Reports are the intrinsic part of assignments and they must be submitted in written to the Co-ordinator within the stipulated time.

Documentation

In tissue banking

Lecture

Donor Data.

Recipient Data.

Tissue harvesting

Processings > pasteurization

Sterilization - workshop

Quality control

Preservation techniques

Cryopreservation

Freeze drying (Lyophilization)

Despatching > Allograft Request

Applications> Surgical Applications of Allografts

Follow up> In charge - Follow up of Donor and Recipients

Complications> Recipients.

Case study> Organs _ (partial) Kidney, Heart, Bone marrow.

Organ transplantation > Observation

MANDATORY RULES OF ASSIGNMENTS FOR MASTER DEGREE

Donor Data: Every student must collect data from the Organ Transplant Co-ordinator and the Forensic Department. The first case of data recipient, should be done by the student independently. 2nd case and hence forth the data shall be collected in the prescribed format of the Bangkok Biomaterial Center.

Tissue Harvesting: Each student should do independent harvesting from at-least 2 cases of brain dead donor, 2 cases of Dead donor and 2 cases of Living donor.

Documentation: Mandatory for all the students after the first case. Every student has to submit reports of each and every assignment strictly of the assignment submission date as stipulated by the Co-ordinator.

Processing: Every student must do each step of processing independently at least 5 times. The reports must follow Processing.

Practical application of Sterilization i.e. Autoclave, ETO and Gamma Radiation. The first two must be done by every student at least 3 times each. The last i.e Gamma Irradiation must be done 5 times by each student.

Application: Every student must observe 10 cases of live application of Tissue and bone allograft and assist in atleast 1 case of every type of application.

Data Review: Every student has to do data review of 200 cases of Allograft recipients and 100 Tissue Donor.

 

FACULTY

 REGULAR LECTURERS / TEACHING STAFFf

1. Mr. Yongyudh Vajaradul Professor M.D., Dr. med. Facharzt fuer  Orthopaedie, Sportarzt, F.I.M.S.,F.I.C.S, F.R.C.S(T)
2. Ms. Suttipant Sarasombath Professor M.D.,Cert. In Pathology, Dip. Amer. Board of Pathology, Dip. Amer. Board Nuclear Medicine,
3. Ms. Chantapong Wasi Associate Professor M.D.,Diploma in Clinical Science (Paediatric)
4. Mr. Sommart Keorochana Professor F.I.C.S., F.R.C.S.(T), F.I.M.S.
5. Mr. Surapol Issarakrisil Professor M.D., Dip. Thai Board of Int Med & Hematology
6. Mr. Sriprasit Boonvisut Assistant Professor B.Sc, M.D, Grad. Dip in Surgery, Dip. Thai Board of Plastic Surgery, F.R.C.S(T)., F.I.C.S.
7. Mr. Surasak Muangsombut Assistant Professor M.D., Dip. Amer. Board of Plastic Surgery Dip. Thai Board of Plastic Surgery, F.R.C.S(T)
8. Mr. Somsak Masomboon Assistant Professor M.D., F.R.C.S. (T), F.I.C.S. (Plastic)
9. Ms. Malinee Prasitsilp Lecturer B.Sc. (Materials Science)                                    Ph.D. (Bioengineering)
10. Ms. Siriporn Thitilertdecha Assistant Professor B.Sc. (Physiotherapy), M.Sc. (Anatomy)
11. Ms. Sontana Siritantikorn Assistant Professor B.Sc (Biology), M.Sc. (Trop. Med.)Dr. rer   nat.(Bio)
12. Mr. Prasit Gonggetyai Associate Professor   M.D., F.R.C.S., F.I.C.S., F.I.M.S., F.R.C.S(T)., Dip. Thai Board of Orthop. Surg., Dip. Amer. Board of Orthop. Surg.
13. Mr. Pricha Rakpolmuang Assistant Professor Dip. Thai Board of Orthop. Surg., Dip. Amer. Board of Orthop. Surg
14. Mr. Saranatra Waikakul Associate Professor  M.D., F.I.M.S., F.R.C.S.(T), Dip. Thai Board of Orthop. Surg.
15. Mr. Teerawat Kulthanan Associate Professor M.D., F.I.M.S., F.I.C.S., F.R.C.S.(T), Dip. Thai Board of Orthop. Surg.
16. Mr. Vatanachai Rojvanit Associate Professor M.D., D.M.Sc.,F.A.C.S., F.R.C.S.(T), F.I.C.S., F.I.M.S., Grad. Dip. In Clin. Sc. (Surgery), Dip. Thai Board of Orthop. Surg.
17. Mr. Kamolporn Assistant Professor M.D., Dip. Thai Board of Orthop. Surg.  Kaewpornsawan DIS-Chirurqie Orthopedique (PARIS) F.I.C.S., F.I.M.S., F.R.C.S.(T)
18. Ms. Jarunee Thongphasuk -    B.Sc. (Medical Technology) M.Sc. Radiation Biology) Ph.D. (Radiation Biology)
19. Mr. Keerati Chareancholvanich -   M.D., Dip. Thai Board of Ortho Surg, F.I.M.S
20. Mr. Apichat Asavamongkolkul - M.D, Dip. Thai Board of Ortho Surg, F.I.M.S
21. Ms. Supa Rochawuttanon -   B.Sc., D.D.S., Cert. Fellowship Training in Oral & Maxillofacial Surgery, Medical College of Georgia, U.S.A.
22. Ms. Chanida Kanchanalarp - M.D, Facharzt fur Otolaryngology

 

VISITING LECTURERS

1. Mr. Manoon Aramrattana - B.Sc. (Electrical Engineering) M.Sc. (Electrical Engineering) Ph.D. (Electrical Engineering)
2. Ms. Chaweewan Jaruwan - B.Sc., D.V.M, Cert. in Animal Health & Production (A.R.E.), Dip. in Pig Husbandry (The Netherlands)
3 .Mr. Weerachai Kosuwon Associate Professor Dip. Thai Board in Orthopaedic Surgery, M.Sc. (Clinical Epidemiology & HealthEconomics), F.I.M.S.
4. Ms. Thitiwan Thaprat - Cert. in Periodontics,M.S.
5. Mr. Nares Damrongchai - B.Sc. (Bioengineering) M.Sc. (Bioengineering) Ph.D. (Bioengineering)
6. Mr. Wiroon Laupattarakasem Professor B.Sc. M.D. Cert. in Clinical Science, F.I.M.S., F.I.C.S., F.R.C.S.T.
7. Mr. Thanit Pewnim Assistant Professor B.Sc. (Biochemistry) M.Sc. (Biochemistry) Ph.D. (Biochemistry)
8. Mr. Weerasak Phairachvej Assistant Professor B.Sc. M.D. Cert. in Clinical Science, F.I.M.S., F.I.C.S., F.R.C.S.T.

IAEA EXPERT LECTURERS

1. Mr. RUdiger von Versen,Germany    Associate Professor M.D., PhD (Biochemistry)
2. Ms. Barbara Wilke Germany Scientist MSc, PhD (Biochemistry)
3. Ms. Norimah Yusof , Malaysia Scientist   B.Sc. (Genetics) M.Sc.(Radiation Biology) Ph.D.(Radiotherapy in Cancer Research)
4. Mr. Abdul Rab Khan , Pakistan Scientist M.C.P.S.(Radiotherapy), M.B.B.S.
5. Mr. Norberto R. Agcaoili Professor   M.D. (Orthopaedics)
6. Mr. Douglas M. Strong ,USA    Scientist   B.Sc.(Medical Technology) Ph.D.(Pathology)
7. Mr. William W. Tomford, USA    Professor M.D (Orthopaedics)  Ph.D. (Radiotherapy in Cancer Research)  M.C.P.S.(Radiotherapy), M.B.B.S.
8. Ms.Anna  dziedzic-Goclawska Poland Professor M.D., Ph.D. (Hitology and Embryology) Poland
9. Mr.Geoffrey Burwell ,U.K Professor B.Sc., M.D., F.R.C.S.
10. Ms. Nazly Hilmy, Indonesia Scientist      MSc, PhD

         

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Fig 1: First Batch of Advance Training Course -Cum- Master Degree Programme Students pose with Prof. Yongyudh Vajaradul - Course Supervisor and Director, Bangkok Biomaterial Center and his team.

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Prof. Yongyudh Vajaradul - Course Director giving the Diploma Certificate to IAEA Fellow Mr. Go Bon Thong of Malaysia

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Prof. Yongyudh Vajaradul - Course Director giving the Diploma Certificate to IAEA Fellow Mr. Basril Abbas of Indonesia

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Prof. Yongyudh Vajaradul - Course Director giving the Souvenier to IAEA Fellow Mr. H.P. Jayathilaka from Sri Lanka

 

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